(PIBD-SETQuality) Paediatric Inflammatory Bowel Diseases Network for Safety, Efficacy, Treatment and Quality improvement of care

Project summary

“The incidence of paediatric onset Inflammatory Bowel Diseases (PIBD) has risen dramatically in recent decades. PIBD reflects a more severe disease than its adult forms, requiring aggressive treatment with immunomodulators, that leads to a life-long risk of serious disease and treatment-related adverse events. Therefore, there is an urgent need to develop strategies which balance, on an individual basis, therapeutic effectiveness with risks of treatment.
The overall goal of this proposal is to develop and validate a treatment algorithm for PIBD based on high or low risk predictors for early complicated or relapsing disease. This will improve effectiveness, while reducing treatment related risks and life-long complications due to uncontrolled disease progression.

The major goal of this proposal is to develop and validate for the first time a risk-stratified individualized treatment algorithm for children with PIBD that will improve effectiveness, while reducing treatment related risks and life-long complications due to uncontrolled disease progression.